Senior Laboratory Research Scientist

The Francis Crick Institute
Romford
1 month ago
Applications closed

Related Jobs

View all jobs

Senior Project Engineer

Senior Solutions Architect

Senior Electronics Engineer

Senior Systems Engineer

Senior Golang Developer - 2 Day London - Inside IR35

Senior Pricing Analyst

Job Title: Senior Laboratory Research Scientist – Structural Biochemist (SLRS) 

Details of the role: 2 yr fixed term, full-time. Working pattern: Monday – Friday. 

Salary: From £44,360 with benefits, dependent on skills and experience 

Application closing date: 02/05/25 23:59 GMT

 

About us…   

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.  

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.  

About the role…  

 The Enchev Lab is offering a unique opportunity to get involved in developing and applying methods for directly observing biochemical processes at atomic spatial and millisecond time resolution. Our work combines microfluidics devices to mix and incubate biochemical samples on sub-second timescales with rapid spray-plunge freezing for subsequent three-dimensional structure determination by time-resolved cryo-EM (trEM). By iterating this procedure at increasing incubation times and using machine learning-based approaches to map conformational landscapes, we generate time-lapse "movies" of biochemical binding and enzymatic reactions. 

This role will support academic and industry collaborations and early-stage proof-of-concept trEM studies. Team working and an open mind as to how other disciplines and technologies can advance our work are critical.

Projects may vary in scope and duration. A representative example includes cloning, recombinant production, and biochemical purification of Cullin-RING ligases and their substrates, followed by biochemical characterization, time-resolved cryo-EM sample preparation, data collection, and analysis.   

What you will be doing…  

As anSLRSat the Crick, you will be involved in:  

Protein Expression and Purification  

  • Design and generate protein expression constructs.  
  • Express recombinant proteins using bacterial and insect cell systems.  
  • Purify recombinant proteins using affinity, ion exchange, and size exclusion chromatography.  

Biochemical and Structural Characterization  

  • Conduct quantitative biochemical binding and activity assays  
  • Carry out standard as well as time-resolved cryo-EM sample preparation.  
  • Independently perform single-particle cryo-EM screening and data collection.  
  • Process single-particle cryo-EM datasets.   
  • Perform model building into high-resolution cryo-EM maps. 

 

About you…   

The essential criteria you will bring…  

  • PhD in biochemistry (or related fields) or equivalent experience  
  • Practical experience with protein expression, purification and in vitro protein biochemistry  
  • Theoretical and practical expertise in cryo-electron microscopy, single particle analysis and model building  
  • Track record of writing papers as evidenced by preprints and/or publications in peer-reviewed journals  
  • Ability to work flexibly, both independently and as part of a team  
  • Evidence of data presentation at scientific meetings 

To see the complete job description, clickhere

To see more about the Group Leader clickhere

About Working at the Crick…  

Ourvalues   

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!  

We are bold.We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.  

We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.  

We are collegial. We show respect for one another, work cooperatively and support the wider community.  

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under theDisability Confidentscheme.  We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email:  

To find out more about life at the Crick clickhere

What will you receive?   

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:  

Visas: Applicants for this role will be eligible for sponsorship to work in the UK  

Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.  

Pension Scheme: Defined contribution pension with employer contributions of up to 16%.  

Health & Well-being:  

  • 24/7 GP consultation services.  
  • Occupational health services and mental health support programs.  
  • Eye care vouchers and discounted healthcare plans.  

Work-Life Balance:  

  • Back-up care for dependents.  
  • Childcare support allowance.  
  • Annual leave purchase options.  
  • Crick Networks offering diverse groups’ support, community and inclusive social events. 

Perks:  

  • Discounted gym memberships, bike-to-work scheme, and shopping discounts.  
  • Subsidised on-site restaurant and social spaces for team interaction.  

Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience. 

 

Get the latest insights and jobs direct. Sign up for our newsletter.

By subscribing you agree to our privacy policy and terms of service.

Industry Insights

Discover insightful articles, industry insights, expert tips, and curated resources.

AI Engineer World’s Fair 2025: The Complete UK Guide to June’s Unmissable AI Engineering Event

If 2024 was the year every product team rushed to bolt an LLM onto their roadmap, 2025 is when the craft of AI engineering finally takes centre stage. From rapid-fire prompt iterations to robust eval pipelines, the discipline now demands the same rigour we once reserved for cloud infra or mobile apps. That is precisely why the AI Engineer World’s Fair, 3–5 June 2025 in San Francisco, matters more than any keynote or press release: it is the one place where the movers, makers and maintainers of production-grade AI swap battle-tested patterns in person. For UK technologists—and the recruiters who hire them—the Fair offers a rare chance to compress a year’s worth of learning, networking and tooling discovery into three intense days. Whether you are scaling RAG systems on Azure, bootstrapping an agentic start-up from your kitchen table, or simply hunting for your first AI engineer job, the sessions, workshops and hallway conversations can tilt your career trajectory. The guide that follows distils everything you need to know—programme highlights, travel hacks, ticket tips and post-event ROI—so you can decide if a flight across the Atlantic (or a virtual pass) is the smartest investment you’ll make this year.

How to Advertise AI Jobs and List AI Vacancies: Advanced Recruitment Strategies for 2025

In a landscape where artificial intelligence (AI) is rapidly transforming industries—from healthcare and finance to manufacturing and creative fields—employers are in stiff competition to secure the best AI talent. Whether you’re a start-up looking for your first machine learning engineer or a global enterprise planning an AI research lab, knowing how to advertise AI jobs effectively has never been more critical. Below, you’ll find in-depth strategies for crafting compelling AI job adverts, optimising your recruitment funnel, and showcasing your organisation as an employer of choice for top AI specialists. We’ll also explore the importance of salary transparency, the best channels for promoting your AI vacancies, and advanced techniques for nurturing a culture of innovation.

AI Training Jobs: Your Comprehensive Guide to Launching a High-Potential Career

Artificial Intelligence (AI) has evolved from a futuristic concept to a core component of modern business strategy. As organisations increasingly embrace AI-driven systems to stay competitive, the demand for qualified professionals who can develop, implement, and train AI models has skyrocketed. In the UK—and indeed worldwide—there is a pressing need for skilled experts who understand the nuances of AI, from algorithm design to ethical considerations. For anyone seeking to enter this exciting field or pivot into a role focusing on AI training, the opportunities are abundant. This in-depth blog post will explore everything you need to know about AI training jobs, the essential skills you’ll need, the current employment landscape in the UK, and how to future-proof your career in AI.