Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.

About the Role:

We have an exciting opportunity for a Postdoctoral Fellow to join the Taipale group for a 2-year fixed-term contract with the potential to extend.

The laboratory consists of experimental biologists and computer scientists who focus on the study of transcriptional control of cell growth, using functional genomics and systems biology, and mouse genetic models.

You will be responsible for:

• Development of technologies and methods for the study of gene expression using genomics and computational approaches, for example setting up advanced methods for parallel genomic integration of large DNA payloads
  
• Writing up manuscripts, communicating results through talking, presenting posters at scientific meetings
  
• Collaborate with internal teams and external collaborators to ensure project progress and provide regular updates
  
• Taking an active part in your development, including attending training and being an active member of our Postdoctoral Fellow community
  

About You:

Applicants should have, or will soon have, a PhD in computational biology, molecular biology, genetics, or biochemistry.

The successful applicant will also have flexibility within the role to pursue an independent research project in the general remit of gene expression in relation to the grant. Candidates with interest or experience in machine learning, artificial intelligence and programming are encouraged to apply.

You will have excellent communication skills and the ability to communicate effectively with stakeholders.

For more information about being a Postdoctoral Fellow with us, please visit:https://youtu.be/1-vxm2nBmFA

About Us:

The Taipale group is newly established at the Wellcome Sanger Institute.

Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, and using this information to identify regulatory elements that control cell growth during normal development and in cancer (see, for example Hallikas et al., Cell 124:47-59, 2006; Sur et al., Science 338:1360-1363, 2012; Jolma et al., Cell 152:327-339, 2013; Jolma et al., Nature 527:384-388, 2015; Yin et al., Science 356:eaaj2239, 2017; Zhu et al., Nature 562:76-81, 2018; Yan et al., Nature 591:147-151, 2021; Sahu et al., Nature Genetics 54:283-294, 2022).

The lab benefits from access to cutting-edge facilities at the Wellcome Sanger Institute such as DNA sequencing, Cell Operations and Automation.

We aim to decipher the regulatory genetic code using random DNA and measuring its activity using experimental and AI models (see Nature 625, 41-50, 2024). The work profile will be a combination of wet-lab and dry-lab tasks.

Other Information:

Please apply with your CV and a Cover Letter outlining how you meet the criteria set out above. Please also indicate in your cover letter why you are interested in joining the Taipale group and this research area.

Salary:£38,000 - £45,413 depending on experience.

Closing Date:2nd February 2025

Contract duration:2-years fixed term

Role profile:For the full list of accountabilities and criteria, please click here.

View our 2023-2024 Institute Highlights here: bit.ly/SangerHighlights2023-24

Hybrid Working at Wellcome Sanger:

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity and Inclusion:

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.