National AI Awards 2025Discover AI's trailblazers! Join us to celebrate innovation and nominate industry leaders.

Nominate & Attend

Senior Laboratory Research Scientist – Structural Biochemist, Visual Biochemistry lab

The Francis Crick Institute
London
2 months ago
Applications closed

Related Jobs

View all jobs

Research Associate in Soft Robotics and Machine Learning (KK12496R)

Senior Scientist – Functional materials, thin films and coatings

Senior Scientist – Functional materials science and particle chemistry

Laboratory Technician (Sensor testing laboratory)

Closed-loop design of heat-resistant austenitic alloys through iterative machine learning and c[...]

Principal Scientist

Description

:

Job title:Senior Laboratory Research Scientist – Structural Biochemist, Visual Biochemistry lab

Details of the role:2 yr fixed term, full-time. Working pattern: Monday – Friday.

Salary: From £44,360 with benefits, dependent on skills and experience

Application closing date:11th April 2025 23:59 GMT

About us… 

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. 

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. 

About the role… 

The Enchev Lab is offering a unique opportunity to get involved in developing and applying methods for directly observing biochemical processes at atomic spatial and millisecond time resolution. Our work combines microfluidics devices to mix and incubate biochemical samples on sub-second timescales with rapid spray-plunge freezing for subsequent three-dimensional structure determination by time-resolved cryo-EM (trEM). By iterating this procedure at increasing incubation times and using machine learning-based approaches to map conformational landscapes, we generate time-lapse "movies" of biochemical binding and enzymatic reactions.

This role will support academic and industry collaborations and early-stage proof-of-concept trEM studies. Team working and an open mindas to how other disciplines and technologies can advance our work are critical.

Projects may vary in scope and duration. A representative example includes cloning, recombinant production, and biochemical purification of Cullin-RING ligases and their substrates, followed by biochemical characterization, time-resolved cryo-EM sample preparation, data collection, and analysis.

What you will be doing… 

AsanSLRSat the Crick, you will be involved in:

Protein Expression and Purification 

Design and generate protein expression constructs. 

Express recombinant proteins using bacterial and insect cell systems. 

Purify recombinant proteins using affinity, ion exchange, and size exclusion chromatography. 

Biochemical and Structural Characterization 

Conduct quantitative biochemical binding and activity assays 

Carry out standard as well as time-resolved cryo-EM sample preparation. 

Independently perform single-particle cryo-EM screening and data collection. 

Process single-particle cryo-EM datasets. 

Perform model building into high-resolution cryo-EM maps.

About you…

The essential criteria you will bring… 

PhD in biochemistry (or related fields) or equivalent experience 

Practical experience with protein expression, purification and in vitro protein biochemistry 

Theoretical and practical expertise in cryo-electron microscopy, single particle analysis and model building 

Track record of writing papers as evidenced by preprints and/or publications in peer-reviewed journals 

Ability to work flexibly, both independently and as part of a team 

Evidence of data presentation at scientific meetings

To see the complete job description, click.

To see more about the Group Leader click.

About Working at the Crick… 

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture! 

We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently. 

We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. 

We are collegial. We show respect for one another, work cooperatively and support the wider community. 

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: k

To find out more about life at the Crick click .

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: 

Visas:Applicants for this role will be eligible for sponsorship to work in the UK

Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. 

Pension Scheme: Defined contribution pension with employer contributions of up to 16%. 

Health & Well-being: 

24/7 GP consultation services. 

Occupational health services and mental health support programs. 

Eye care vouchers and discounted healthcare plans. 

Work-Life Balance: 

Back-up care for dependents. 

Childcare support allowance. 

Annual leave purchase options. 

Crick Networks offering diverse groups’ support, community and inclusive social events.

Perks: 

Discounted gym memberships, bike-to-work scheme, and shopping discounts. 

Subsidised on-site restaurant and social spaces for team interaction. 

Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

National AI Awards 2025

Subscribe to Future Tech Insights for the latest jobs & insights, direct to your inbox.

By subscribing, you agree to our privacy policy and terms of service.

Industry Insights

Discover insightful articles, industry insights, expert tips, and curated resources.

AI Jobs Salary Calculator 2025: Work Out Your Market Value in Seconds

Why your 2024 salary data is already outdated “Am I being paid what I’m worth?” It is the question that creeps in whenever you update your CV, see a former colleague announce a punchy pay rise on LinkedIn, or notice a recruiter slide into your inbox with a role that looks eerily similar to your current one—only advertised at £20k more. Artificial intelligence moves faster than any other hiring market. New frameworks are open‑sourced overnight, venture capital floods specific niches without warning, & entire job titles—Prompt Engineer, LLM Ops Specialist—appear in the time it takes most industries to schedule a meeting. In that environment, salary guides published only a year ago already look like historical curiosities. To give AI professionals an up‑to‑the‑minute benchmark, ArtificialIntelligenceJobs.co.uk has built a simple yet powerful salary‑calculation formula. By combining three variables—role, UK region, & seniority—you can estimate a realistic 2025 salary band in less than a minute. This article explains that formula, unpacks the latest trends driving pay, & offers concrete steps to boost your personal market value over the next 90 days.

How to Present AI Models to Non-Technical Audiences: A Public Speaking Guide for Job Seekers

In today’s competitive job market, AI professionals are expected to do more than just build brilliant algorithms—they must also explain them clearly to stakeholders who may have no technical background. Whether you're applying for a role as a machine learning engineer, data scientist, or AI consultant, your ability to articulate complex models in simple terms is fast becoming one of the most valued soft skills in interviews and on the job. This guide will help you master the art of public speaking for AI roles, offering tips on structuring presentations, designing effective slides, and using storytelling to make your work resonate with any audience.

AI Jobs UK 2025: 50 Companies Hiring Now

Bookmark this guide – we refresh it every quarter so you always know who’s really scaling their artificial‑intelligence teams. Artificial intelligence hiring has roared back in 2025. The UK’s boosted National AI Strategy funding, record‑breaking private investment (£18.1 billion so far) & a fresh wave of generative‑AI product launches mean employers are jockeying for data scientists, ML engineers, MLOps specialists, AI product managers, prompt engineers & applied researchers. Below are 50 organisations that have advertised UK‑based AI vacancies in the past eight weeks or formally announced growth plans. They’re grouped into five easy‑scan categories so you can jump straight to the kind of employer – & culture – that suits you. For each company you’ll find: Main UK hub Example live or recent vacancy Why it’s worth a look (tech stack, culture, mission) Use the internal links to browse current vacancies on ArtificialIntelligenceJobs.co.uk – or set up a free job alert so fresh roles land in your inbox.